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A combination therapy regimen consisting of bevacizumab (a recombinant humanized monoclonal IgG1 antibody that inhibits vascular endothelial growth factor), carboplatin (a platinum-based chemotherapy agent), icotinib (an EGFR tyrosine kinase inhibitor), and pemetrexed (a folate analog that inhibits multiple enzymes in folate metabolism). This combination likely targets multiple cancer pathways simultaneously, including angiogenesis (bevacizumab), DNA synthesis (carboplatin), EGFR signaling (icotinib), and folate metabolism (pemetrexed).
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