Drug intelligence / Profile preview

bevacizumab + carboplatin + icotinib + pemetrexed

Development stage
Preclinical
Lead developer
Genentech
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous, Oral
01

Overview

A combination therapy regimen consisting of bevacizumab (a recombinant humanized monoclonal IgG1 antibody that inhibits vascular endothelial growth factor), carboplatin (a platinum-based chemotherapy agent), icotinib (an EGFR tyrosine kinase inhibitor), and pemetrexed (a folate analog that inhibits multiple enzymes in folate metabolism). This combination likely targets multiple cancer pathways simultaneously, including angiogenesis (bevacizumab), DNA synthesis (carboplatin), EGFR signaling (icotinib), and folate metabolism (pemetrexed).

02

Targets

DNADHFR (Dihydrofolate reductase)TS (Thymidylate synthase)VEGFA (Vascular endothelial growth factor A)EGFR (Epidermal growth factor receptor)

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