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Combination therapy consisting of bevacizumab (Avastin), an anti-VEGF monoclonal antibody, and ofranergene obadenovec (VB-111), a novel anticancer viral therapy. Ofranergene obadenovec utilizes a proprietary Vascular Targeting System to target tumor vasculature and induce cell death in angiogenic endothelial cells while also triggering an anti-tumor immune response with CD8 T-cell recruitment.
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