Drug intelligence / Profile preview

bevacizumab + ofranergene obadenovec

Development stage
Discontinued
Lead developer
VBL Therapeutics
Modality
Gene Therapies, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

Combination therapy consisting of bevacizumab (Avastin), an anti-VEGF monoclonal antibody, and ofranergene obadenovec (VB-111), a novel anticancer viral therapy. Ofranergene obadenovec utilizes a proprietary Vascular Targeting System to target tumor vasculature and induce cell death in angiogenic endothelial cells while also triggering an anti-tumor immune response with CD8 T-cell recruitment.

Brand names
Avastin + VB-111
Other names
ofra-vec + bevacizumab
02

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