Drug intelligence / Profile preview

bevacizumab + paclitaxel + vorinostat

Development stage: Unknown
Lead developer: Genentech
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration: Oral, Intravenous

Overview

A combination therapy consisting of bevacizumab (an anti-angiogenic monoclonal antibody targeting VEGF), paclitaxel (a microtubule-stabilizing chemotherapeutic agent), and vorinostat (a histone deacetylase inhibitor). This regimen has been studied primarily for metastatic breast cancer, where vorinostat induces histone and alpha tubulin acetylation and functionally inhibits Hsp90 in breast cancer cells, potentially enhancing the efficacy of paclitaxel and bevacizumab.

Targets

TUBB (Tubulin (alpha and beta subunits))HSP90 (Heat shock protein 90 chaperone complex)HDAC (HDAC family)VEGFA (Vascular endothelial growth factor A)

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