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bevacizumab + vandetanib
- Development stage
- Unknown
- Lead developer
- Genentech
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules, Irreversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous, Oral
01
Overview
Bevacizumab + vandetanib is an investigational combination therapy consisting of two targeted agents used in oncology. Bevacizumab is a monoclonal antibody that binds to and inhibits vascular endothelial growth factor (VEGF), thereby blocking angiogenesis. Vandetanib is a small molecule tyrosine kinase inhibitor with activity against VEGF receptor 2 (VEGFR2), epidermal growth factor receptor (EGFR), and RET receptor. The rationale for combining these drugs is to achieve dual blockade of the VEGF pathway and inhibit tumor angiogenesis more effectively than either agent alone. This combination has been evaluated in phase I clinical trials for patients with advanced solid tumors and lymphomas, demonstrating preliminary evidence of anti-tumor activity and manageable toxicity profiles[1][2].
02
Targets
VEGFR2 (Vascular endothelial growth factor receptor 2)RET (Rearranged during transfection receptor tyrosine kinase)VEGFA (Vascular endothelial growth factor A)EGFR T790M (Epidermal growth factor receptor T790M mutant)
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