Drug intelligence / Profile preview

BGB-A445 + BGB-15025

Development stage: Unknown
Lead developer: BeiGene
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration: Intravenous

Overview

**BGB-A445 + BGB-15025** is an investigational combination regimen for cancer therapy currently under clinical evaluation for advanced solid tumors, with a focus on advanced non-small cell lung cancer (NSCLC). BGB-A445 is an anti-OX40 agonist monoclonal antibody; it activates OX40 on T cells, thereby enhancing immune cell activation and proliferation to support anti-tumor immunity. BGB-15025 is an investigational inhibitor of Hematopoietic progenitor kinase 1 (HPK1), targeting a negative regulator of T cell receptor signaling to further stimulate T cell responses. The mechanism is based on dual immune activation: OX40 agonism plus HPK1 inhibition, aiming to synergistically amplify cancer immunotherapy efficacy. Both agents are designed and developed by BeiGene[1][2][4][7][9].

Other names: BGB-A445BGB-A-445BGB-A 445BGB-15025BGB15025BGB 15025

Targets

CD28 (Cluster of Differentiation 28)MAP4K1 (Hematopoietic progenitor kinase 1)

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