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BH4 + L-NMMA + ascorbic acid + tocopherol + alpha-lipoic acid + l-ascorbate
- Development stage
- Unknown
- Lead developer
- Russell Richardson
- Modality
- Small Molecules
- Administration
- Oral, Intravenous, Intra-arterial
01
Overview
This combination is a research-focused pharmacological and nutritional intervention designed to probe the nitric oxide (NO) pathway and oxidative stress levels in the human vasculature. It utilizes tetrahydrobiopterin (BH4) to support nitric oxide synthase (NOS) function as a cofactor, N-monomethyl-L-arginine (L-NMMA) to inhibit NOS, and a multi-component antioxidant cocktail consisting of ascorbic acid (Vitamin C), tocopherol (Vitamin E), and alpha-lipoic acid to scavenge reactive oxygen species. By administering these agents, researchers can quantify the relative contributions of NO bioavailability and oxidative stress to blood flow regulation and vascular tone. This specific protocol is primarily associated with the research of Russell Richardson at the University of Utah and the VA Salt Lake City Health Care System, focusing on peripheral vascular function in aging and chronic diseases such as COPD and hypertension.
- Other names
- Antioxidant cocktail + BH4 + L-NMMABH4, L-NMMA, Vitamin C, Vitamin E, alpha-Lipoic Acid and L-Ascorbate
02
Targets
NOS1 (nNOS)NOS (Nitric oxide synthase traffic inducer)
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