Drug intelligence / Profile preview

bhumiamalaki + siddha makardwaja

Development stage
Preclinical
Modality
Nanoparticles → Drug Delivery Systems
Administration
Oral
01

Overview

Bhumiamalaki + Siddha Makardwaja is an Ayurvedic combination therapy primarily investigated for the treatment of Non-Alcoholic Steatohepatitis (NASH) and liver fibrosis. The therapy consists of Bhumiamalaki (*Phyllanthus niruri*), an aqueous herbal extract known for its antifibrotic and hepatoprotective properties, and Siddha Makardwaja Rasa, a traditional metallic preparation containing gold nanoparticles (Au/HgO) that acts as a systemic anti-inflammatory agent. The combination is designed to target multiple pathways, including the regulation of hepatic lipid metabolism, reduction of pro-inflammatory cytokines, and the reversal of liver stiffness and fibrosis. Clinical case studies have demonstrated its potential to reduce Liver Stiffness Measurement (LSM) and Controlled Attenuation Parameter (CAP) scores in patients with NASH.

Other names
Phyllanthus niruri + Siddha Makardwaja RasaBhumiamalaki + Siddha Makardwaja Rasa

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