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BI-1910 + pembrolizumab is a combination therapy under investigation for the treatment of advanced or metastatic solid tumors whose disease has progressed after standard therapy. BI-1910 is a monoclonal antibody that targets Tumor Necrosis Factor Receptor 2 (TNFR2), modulating immune responses and potentially enhancing anti-tumor immunity. Pembrolizumab (brand name: Keytruda) is a monoclonal antibody that blocks the programmed death-1 (PD-1) receptor, thereby restoring T cell activity against tumors. The combination aims to utilize dual immune modulation by blocking inhibitory signals (PD-1) and targeting TNFR2-expressing regulatory cells within the tumor microenvironment.
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