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BI 894416 + itraconazole
- Development stage
- Unknown
- Lead developer
- Boehringer Ingelheim
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**BI 894416 + itraconazole** is a combination of a clinical-stage investigational drug (BI 894416, developed by Boehringer Ingelheim) and a widely used antifungal agent, **itraconazole**. While specific details on BI 894416 are limited in public sources, itraconazole is a broad-spectrum triazole antifungal. It inhibits fungal cell membrane synthesis by blocking lanosterol 14-alpha demethylase, an enzyme essential for converting lanosterol to ergosterol, thereby compromising cell membrane integrity[2][5]. Itraconazole is used in the treatment of systemic and superficial fungal infections. This combination may be used in clinical trials to study drug-drug interactions or the effect of CYP3A4 inhibition on the pharmacokinetics of BI 894416, since itraconazole is a potent inhibitor of CYP3A4 and drug transporters like P-glycoprotein[1][5].
- Other names
- BI 894416BI894416BI-894416itraconazole
02
Targets
STAT3 (Signal Transducer and Activator of Transcription 3)ABCB1 (P-glycoprotein)CYP51A1 (Sterol 14α-demethylase)CYP3A4 (Cytochrome P450 3A4)PIK3R1 (Phosphoinositide-3-kinase regulatory subunit 1)
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