BIBR 1048 + pantoprazole

This is a **combination** of BIBR 1048 (dabigatran etexilate), an oral prodrug anticoagulant that is rapidly converted in vivo to dabigatran, and **pantoprazole**, a proton pump inhibitor. Dabigatran etexilate is a direct, reversible thrombin inhibitor used for stroke prevention in atrial fibrillation and prevention/treatment of venous thromboembolism. Pantoprazole is used to reduce gastric acid secretion, often to prevent gastrointestinal side effects from other drugs. This combination is primarily relevant for studying drug-drug interactions, as co-administration results in a decrease in dabigatran exposure (bioavailability reduced by 29-30%), attributed to pH-dependent reduction in absorption of dabigatran etexilate.

Brand names

PradaxaProtonix

Other names

dabigatran etexilate + pantoprazole