Drug intelligence / Profile preview

bicalutamide + fluciclovine F 18

Development stage
Unknown
Lead developer
Blue Earth Diagnostics
Modality
Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Oral, Intravenous
01

Overview

This is a combination of bicalutamide, a nonsteroidal anti-androgen medication used for treating prostate cancer, and fluciclovine F 18, a radiopharmaceutical used for positron emission tomography (PET) imaging to detect recurrent prostate cancer. Bicalutamide blocks androgen receptors to inhibit the growth of prostate cancer cells, while fluciclovine F 18 helps in diagnostic imaging to detect prostate cancer recurrence.

Brand names
Posluma
Other names
flotufolastat F 18
02

Targets

SLC1A5 (Alanine/serine/cysteine transporter 2)AR (Adrenergic receptors)

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