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synergistic combination of a probiotic (Bifidobacterium species such as Bifidobacterium animalis subsp. lactis, Bifidobacterium longum, or Bifidobacterium infantis) and a prebiotic (inulin, a fructo-oligosaccharide derived from plants such as chicory) administered together as a synbiotic. Bifidobacterium species colonize the colon, promoting gut health, immune modulation, and metabolic benefits. Inulin serves as a fermentable substrate selectively utilized by Bifidobacterium, enhancing their growth and activity, which leads to increased production of short-chain fatty acids (SCFAs) like acetate. SCFAs interact with G protein-coupled receptors in the gut and may improve glucose tolerance, fatty acid oxidation, and lower visceral fat. The combination is marketed primarily as a functional food, dietary supplement, or food ingredient, not typically as a registered pharmaceutical drug. Its primary indications include improving gut microbiota composition, supporting gastrointestinal health, and, in some studies, reducing visceral adiposity or improving metabolic markers in overweight individuals[4][5][2][3].
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