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bifidobacterium lactis HN019 + lactobacillus acidophilus NCFM + lacticaseibacillus rhamnosus HN001 + lacticaseibacillus paracasei Lpc-37

Development stage
Unknown
Lead developer
International Flavors & Fragrances
Modality
Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral
01

Overview

**Bifidobacterium lactis HN019 + Lactobacillus acidophilus NCFM + Lacticaseibacillus rhamnosus HN001 + Lacticaseibacillus paracasei Lpc-37** is a multi-strain probiotic formulation typically marketed as a dietary supplement for improving gastrointestinal health and modulating immune function. Each strain contributes to digestive health by various mechanisms: - **Bifidobacterium lactis HN019**: Promotes gut motility, improves intestinal barrier, and modulates immune function by enhancing phagocytic and NK cell activity. It also increases levels of beneficial gut bacteria and may improve symptoms of constipation, diarrhea, bloating, and abdominal pain, likely by modulating the gut-brain axis and fermentation of short-chain fatty acids[1][2][3]. - **Lactobacillus acidophilus NCFM**: Well-characterized for promoting beneficial gut microbiota, improving lactose digestion, supporting immune function, and reducing gastrointestinal symptoms. - **Lacticaseibacillus rhamnosus HN001**: Known for enhancing both digestive and immune health, reducing atopic diseases, and reinforcing the gut barrier. - **Lacticaseibacillus paracasei Lpc-37**: Supports the balance of gut microbiota and enhances immune responses. The mechanism of action is primarily through modulation of gut microbiota composition, competition with pathogens, restoration of intestinal barrier function, production of short-chain fatty acids, and immune system enhancement. The product is generally developed for relief of digestive symptoms (such as constipation, diarrhea, bloating, IBS), maintenance of healthy gut microbiota, and supporting immune function[1][2][3].

Other names
bifidobacterium animalis subsp. lactis HN019 + lactobacillus acidophilus NCFM + lacticaseibacillus rhamnosus HN001 + lacticaseibacillus paracasei Lpc-37

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