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bifidobacterium tetrad live bacteria tablet placebo + helicobacter pylori quadruple eradication therapy (Hangzhou Grand Biologic Pharmaceutical Inc.)
- Development stage
- Unknown
- Lead developer
- Hangzhou Grand Biologic Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This drug regimen is the placebo-controlled comparator arm used in clinical trials (notably NCT04034641) evaluating the probiotic Si Lian Kang (Bifidobacterium tetrad live bacteria tablets). It consists of a standard bismuth-containing quadruple eradication therapy—comprising esomeprazole, amoxicillin, furazolidone, and bismuth potassium citrate—administered alongside a starch-based placebo. The regimen is designed to treat *Helicobacter pylori* infection by combining acid suppression, multiple antibiotic mechanisms, and the bactericidal properties of bismuth. The trial context focuses on whether adding live probiotics to this standard regimen can reduce common gastrointestinal side effects and improve overall eradication rates.
- Other names
- bismuth-containing quadruple therapyH. pylori quadruple eradication therapyesomeprazole + amoxicillin + furazolidone + bismuth potassium citrate
02
Targets
DNAPBP (Penicillin-binding protein family)ATP4A (Potassium–transporting ATPase alpha chain 1)
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