bifonazole + triamcinolone acetonide

Bifonazole + triamcinolone acetonide is a topical combination therapy consisting of a broad-spectrum imidazole antifungal and a potent synthetic corticosteroid. Bifonazole exerts its antifungal effect by inhibiting the synthesis of ergosterol at two distinct steps: the demethylation of lanosterol via lanosterol 14-alpha-demethylase and the conversion of HMG-CoA to mevalonate via HMG-CoA reductase. This dual inhibition is unique among imidazoles and enhances its fungicidal activity. Triamcinolone acetonide provides symptomatic relief by binding to the glucocorticoid receptor, leading to anti-inflammatory, antipruritic, and vasoconstrictive effects. This combination is primarily indicated for the treatment of superficial fungal infections, such as tinea corporis and tinea cruris, particularly when accompanied by significant inflammation or pruritus. It is developed and manufactured by companies such as Liaoning Dasheng Pharmaceutical in China.

Other names

Bifonazole and Triamcinolone Acetonide Cream