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bimatoprost + timolol ocular insert
- Development stage
- Phase 4
- Lead developer
- Allergan
- Modality
- Small Molecules
- Administration
- Ophthalmic
01
Overview
The bimatoprost + timolol ocular insert is a sustained-release drug delivery system developed by ForSight Vision5 (later acquired by Allergan) for the treatment of open-angle glaucoma and ocular hypertension. The device is a non-invasive, preservative-free peri-ocular ring that rests in the conjunctival fornix, providing continuous elution of both active ingredients over several weeks. Bimatoprost, a prostaglandin analog, lowers intraocular pressure by increasing uveoscleral outflow through the activation of prostaglandin F receptors. Timolol, a non-selective beta-adrenergic antagonist, complements this effect by reducing the production of aqueous humor in the ciliary body. This combination approach aims to improve patient compliance by replacing daily eye drops with a long-acting insert.
- Other names
- Fixed Combination Bimatoprost/Timolol Ocular InsertHelios combination ringBimatoprost/Timolol Ring
02
Targets
ADRB1 (β1)ADRB2 (β2)PTGER (Prostaglandin E2 receptor)PTGFR (Prostaglandin F2 alpha receptor)
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