binimetinib + panitumumab

Binimetinib (MEK162) is a selective small molecule inhibitor of MEK1 and MEK2, key kinases in the MAPK/ERK signaling pathway. Panitumumab is a fully human monoclonal antibody that targets the epidermal growth factor receptor (EGFR), blocking ligand-induced activation and downstream signaling. The combination of binimetinib and panitumumab has been investigated primarily for metastatic colorectal cancer (mCRC), particularly in patients with RAS mutant or wild-type tumors. The rationale for this combination is to overcome resistance to EGFR inhibition by simultaneously targeting both EGFR and the MAPK pathway. Clinical studies have shown that this combination results in substantial toxicity and limited clinical activity, with most patients experiencing significant adverse events such as diarrhea, rash, nausea, vomiting, fatigue, and skin reactions[1][2][10]. The development status remains investigational.

Brand names

Vectibix

Other names

binimetinib + panitumumabMEK162 + panitumumab