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Biodentine + simvastatin

Development stage: Unknown
Lead developer: Septodont
Modality: Small Molecules, Device-based Delivery → Drug Delivery Systems
Administration: Topical

Overview

Biodentine + simvastatin is an experimental combination therapy being investigated for use in vital pulpotomy of primary molars. Biodentine is a bioactive tricalcium silicate-based cement used as a dentin substitute, known for its biocompatibility and ability to induce hydroxyapatite formation at the material-pulp interface. Simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor typically used as a lipid-lowering agent, is included in this formulation for its pleiotropic effects, specifically its ability to promote odontoblastic differentiation of dental pulp stem cells and enhance mineralized tissue barrier formation. The combination aims to improve the success rates of pulpotomy by leveraging the mechanical and bioactive properties of Biodentine alongside the regenerative potential of simvastatin.

Other names: Biodentine and simvastatin combination

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)

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