Drug intelligence / Profile preview

biovaxid + sargramostim

Development stage
Unknown
Lead developer
Genitope
Modality
Cytokines & Interferons → Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
Administration
Subcutaneous
01

Overview

BiovaxId + sargramostim is a combination immunotherapy regimen comprising an autologous tumor-derived immunoglobulin idiotype vaccine (BiovaxId) conjugated to keyhole limpet hemocyanin, administered together with sargramostim (GM-CSF). BiovaxId is designed to stimulate the immune system to mount a tumor-specific response by presenting patient-specific idiotype antigens, while sargramostim acts as an immunostimulant that enhances the recruitment and activation of dendritic cells, supporting a more robust anti-tumor immune response. This combination has been primarily developed for the treatment of follicular B-cell non-Hodgkin's lymphoma, particularly in patients who achieved partial or complete response following chemotherapy[1].

Brand names
MyVaxLeukine
Other names
gm-csfgranulocyte-macrophage colony-stimulating factor
02

Targets

CSF2R (Granulocyte-macrophage colony-stimulating factor receptor)Id (Tumor-specific idiotype immunoglobulin)

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