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bis-octanoyl (R)-1,3-butanediol
- Development stage
- Unknown
- Lead developer
- BHB Therapeutics
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**Bis-octanoyl (R)-1,3-butanediol (BO-BD)** is a novel ketone di-ester (KE) designed to elevate blood beta-hydroxybutyrate (BHB) levels through rapid gastrointestinal hydrolysis into octanoic acid (a medium-chain fatty acid) and (R)-1,3-butanediol. These precursors are absorbed and metabolized in the liver via classical (fatty acid) and non-classical (alcohol dehydrogenase-mediated) ketogenic pathways, producing ketone bodies independently of dietary carbohydrate intake. BO-BD exhibits improved sensory acceptability compared to related esters like bis-hexanoyl (R)-1,3-butanediol (BH-BD), with higher palatability scores for taste and ease of use, supporting its potential incorporation into nutritional supplements for ketosis induction.
- Brand names
- Cognitive Switch
- Other names
- C8 ketone di-esterC-8 ketone di-esterC 8 ketone di-ester
02
Targets
BHB (Beta-hydroxybutyrate)
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