Drug intelligence / Profile preview

bisoprolol + hydrochlorothiazide

Development stage
Unknown
Lead developer
Merck
Modality
Small Molecules
Administration
Oral
01

Overview

**Bisoprolol + hydrochlorothiazide** is an oral fixed-dose antihypertensive combination used to treat hypertension. Bisoprolol is a selective beta-1 adrenergic receptor blocker that lowers heart rate, myocardial contractility, and renin release, while hydrochlorothiazide is a thiazide diuretic that inhibits renal sodium and chloride reabsorption, increasing urinary sodium and water excretion. The complementary mechanisms provide additive blood-pressure reduction and are supplied as once-daily film-coated tablets under brands including Ziac, Lodoz, and Concor plus.

Brand names
BisoHEXAL plusBisoprolol-HCT ArcanaBisoprolol ratiopharmConcor plusEmcoreticEmcoretic MitisLodozZiac
Other names
bisoprolol + HCTZbisoprolol fumarate + hydrochlorothiazidebisoprolol hydrochlorothiazidebisoprolol/hydrochlorothiazidehydrochlorothiazide + bisoprolol
02

Targets

ADRB1 (β1)SLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)

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