Drug intelligence / Profile preview

black cohosh + rhodiola rosea

Development stage
Unknown
Lead developer
EuroPharma
Modality
Small Molecules
Administration
Oral
01

Overview

This is a **combination herbal product** consisting of standardized extracts of **black cohosh** (*Actaea racemosa* L.) and **rhodiola rosea** (*Rhodiola rosea* L.) root. It has been clinically formulated and investigated for the relief of menopausal symptoms. Mechanistically, black cohosh is thought to modulate serotonin receptors and act as a selective estrogen receptor modulator, contributing to relief from vasomotor and neuropsychological menopausal symptoms. Rhodiola rosea is an adaptogen that influences neurotransmitter levels (including serotonin, dopamine, and norepinephrine) and exerts anti-fatigue, anti-stress, and neuroprotective effects. In clinical trials, this combination significantly reduced menopausal symptom scores (e.g., Kupperman Menopausal Index, Menopause Rating Scale) and improved quality of life, particularly emotional and physical health, in women with moderate menopausal symptoms. The combination has demonstrated a favorable safety profile, with adverse event incidence comparable to or less than placebo, and efficacy superior to black cohosh alone, especially in psychological symptoms and overall quality of life[1][2][3][4].

Brand names
Menopause Relief EPMenopause Relief PLUS
Other names
hybrid black cohosh–rose root extractBC-RRRR-BC
02

Targets

HTR1D (5-hydroxytryptamine receptor 1D)ESR1 (ERα)HTR7 (5-hydroxytryptamine receptor 7)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))

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