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black cohosh + St. John's wort
- Development stage
- Unknown
- Lead developer
- Schaper & Brümmer
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Black cohosh + St. John's wort is a fixed-dose combination herbal medicine containing standardized extracts of black cohosh (*Cimicifuga racemosa*) and St. John's wort (*Hypericum perforatum*). It is primarily used to alleviate physical and psychological menopausal (climacteric) symptoms, such as hot flashes, excessive sweating, anxiety, irritability, and depressed mood. The combination leverages the complementary effects of black cohosh, which targets neurovegetative symptoms, and St. John's wort, which addresses mild-to-moderate psychological distress. It is marketed under various brand names, including Remifemin plus in Europe and Feramin Q in South Korea.
- Brand names
- Feramin QFeramin-QGyno-plusGynoplusRemifemin plusRemifemin plus Johanniskraut
- Other names
- Cimicifuga racemosa + Hypericum perforatumCimicifuga racemosa extract + Hypericum perforatum extractblack cohosh and St. John's wortiCR + St. John's wort
02
Targets
HTR7 (5-hydroxytryptamine receptor 7)NET (Norepinephrine Transporter)DAT (Dopamine plasma membrane transport protein)SERT (Sodium-dependent serotonin transporter)
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