Drug intelligence / Profile preview

black cohosh extract + st. john's wort extract

Development stage
Unknown
Lead developer
Schaper & Bruemmer
Modality
Small Molecules
Administration
Oral
01

Overview

Remifemin plus Johanniskraut is an approved herbal medicinal product developed by Schaper & Brümmer for the relief of menopausal symptoms. It is a fixed-dose combination of a dry isopropanolic extract of black cohosh (Cimicifuga racemosa) and a dry extract of St. John's Wort (Hypericum perforatum). The product is indicated for both vasomotor symptoms, such as hot flashes and excessive sweating, and psychological symptoms, including mood changes, nervousness, and irritability. It provides a hormone-free therapeutic option, containing no estrogens or phytoestrogens, and is particularly used in the early stages of menopause or for more severe complaints. The efficacy and safety of the combination have been documented in numerous clinical studies involving over 12,000 patients.

Brand names
Remifemin plus JohanniskrautRemifemin plus
Other names
Remifemin + St. John's WortCimicifuga racemosa extract + Hypericum perforatum extract
02

Targets

SERT (Sodium-dependent serotonin transporter)EAAT (Excitatory amino acid transporters)HTR7 (5-hydroxytryptamine receptor 7)DAT (Dopamine plasma membrane transport protein)CRHR1 (Corticotropin-releasing factor receptor 1)NET (Norepinephrine Transporter)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))

Beyond the preview

Go deeper on black cohosh extract + st. john's wort extract.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on black cohosh extract + st. john's wort extract.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call