blex 404 + azacitidine

**BLEX 404 + azacitidine** is an investigational combination therapy, consisting of BLEX 404—a β-glucan purified from _Grifola frondosa_ (maitake mushroom)—and azacitidine, a pyrimidine nucleoside analogue. BLEX 404 acts as an immune modulator, potentially enhancing immune responses against cancer, while azacitidine works as a DNA methyltransferase inhibitor and cytotoxic agent that incorporates into RNA and DNA to disrupt cellular metabolism and gene expression, reducing aberrant methylation and promoting cell death in myeloid malignancies. This combination aims to synergize immune stimulation with epigenetic modulation for improved antineoplastic efficacy, though structured clinical data for the combination is currently lacking for azacitidine specifically.

Brand names

VidazaAzacitidine AccordAzacitidine BetapharmAzacitidine KabiAzacitidine MylanOnureg

Other names

β-glucan from Grifola frondosamaitake mushroom extract5-azacitidine