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bms-708163 + donepezil
- Development stage
- Phase 1
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
BMS-708163 + donepezil is an experimental combination consisting of BMS-708163, a gamma-secretase inhibitor developed by Bristol Myers Squibb, and donepezil, an acetylcholinesterase inhibitor marketed as Aricept. BMS-708163 selectively blocks gamma-secretase–mediated amyloid precursor protein (APP) cleavage, inhibiting amyloid-beta peptide production implicated in Alzheimer’s disease, with reduced inhibition of the Notch pathway compared to earlier inhibitors[6]. Donepezil inhibits acetylcholinesterase, increasing acetylcholine levels to improve cognition and function in Alzheimer’s disease[5]. This combination was studied to assess pharmacokinetic interactions and safety in healthy subjects and Alzheimer’s patients.
- Other names
- BMS-708163BMS708163BMS 708163donepezilAricept
02
Targets
AcetylcholinesteraseGSEC (Gamma-Secretase Complex)
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