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BMS-986453 (Bristol Myers Squibb, 8883d0)
- Development stage
- Unknown
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
BMS-986453 is a small molecule inhibitor of the transient receptor potential canonical 4 and 5 (TRPC4/5) ion channels. Originally developed through a collaboration between Sanofi and Genentech (as SAR441255), the program was later acquired or licensed by Bristol Myers Squibb. TRPC4 and TRPC5 are non-selective cation channels expressed in brain regions associated with emotional processing, such as the amygdala and hippocampus. By inhibiting these channels, BMS-986453 aims to modulate neuronal excitability and synaptic plasticity, potentially offering a novel therapeutic approach for mood and anxiety disorders. The drug is currently in Phase 1 clinical development, where its safety, tolerability, and pharmacokinetics are being evaluated in healthy participants.
- Other names
- TRPC4/5 inhibitor
02
Targets
BCMA (B-cell maturation antigen)GPRC5DTRPC4 (Transient receptor potential cation channel subfamily C member 4)TRPC5 (Transient receptor potential Canonical-5)
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