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BN-Brachyury + bintrafusp alfa
- Development stage
- Unknown
- Lead developer
- Bavarian Nordic
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Subcutaneous, Intravenous
01
Overview
BN-Brachyury + bintrafusp alfa is a combination immunotherapy approach that pairs a therapeutic cancer vaccine with a bifunctional fusion protein. BN-Brachyury is a prime-boost vaccine consisting of MVA-BN-brachyury-TRICOM (prime) and FPV-Brachyury (boost) designed to induce immune responses against the transcription factor brachyury, which is overexpressed in many solid tumors and plays a role in epithelial-to-mesenchymal transition. Bintrafusp alfa is a bifunctional fusion protein composed of the extracellular domain of TGF-βRII (functioning as a TGF-β "trap") fused to a human IgG1 monoclonal antibody blocking PD-L1. This combination aims to enhance anti-tumor immunity through multiple mechanisms: generating brachyury-specific T cell responses while simultaneously blocking immunosuppressive pathways mediated by TGF-β and PD-L1.
- Other names
- MVA-BN-brachyury-TRICOM + bintrafusp alfaFPV-Brachyury + bintrafusp alfaBN-Brachyury + M7824
02
Targets
T (Brachyury transcription factor)TGFB (GARP–latent transforming growth factor beta 1 complex)CD274 (Programmed cell death protein 1 ligand 1)
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