boceprevir + St John's Wort

This entry refers to the co-administration of boceprevir and St John's Wort (Hypericum perforatum), which was evaluated in a Phase I pharmacokinetic and safety study by the St Stephens Aids Trust. Boceprevir is a small molecule NS3 protease inhibitor used for the treatment of chronic hepatitis C virus (HCV) genotype 1 infection. St John's Wort is an herbal dietary supplement commonly used to manage symptoms of depression, which is a frequent side effect of hepatitis C therapy. The study aimed to determine if St John's Wort, a known inducer of cytochrome P450 enzymes (specifically CYP3A4), would significantly alter the plasma concentrations of boceprevir. Results indicated that co-administration did not have a clinically significant effect on boceprevir levels, suggesting that the two can be safely used together.

Brand names

VictrelisUcalm

Other names

boceprevir + Hypericum perforatum