Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
bone marrow aspirate concentrate (Cardiogenesis)
- Development stage
- Discontinued
- Lead developer
- Cardiogenesis
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intramyocardial
01
Overview
This autologous cell-based therapy involves the use of **bone marrow aspirate concentrate (BMAC)** in combination with **transmyocardial revascularization (TMR)** for the treatment of refractory angina pectoris. The procedure utilizes the **PHOENIX Combination Delivery System**, which employs a Holmium:YAG laser to create channels in the ischemic myocardium (TMR) while simultaneously injecting concentrated autologous bone marrow-derived stem cells directly into the heart tissue. The therapy is designed for patients with diffuse coronary artery disease who are not candidates for conventional revascularization procedures like CABG or PCI. The mechanism of action relies on the concentrated stem cells' ability to secrete angiogenic growth factors and the mechanical/thermal stimulus of the laser to promote neovascularization and improve myocardial perfusion. Developed by **Cardiogenesis Corporation** (a subsidiary of **Artivion**, formerly **CryoLife**), the PHOENIX system received CE Mark approval in 2006 but has not received FDA approval in the United States.
- Brand names
- PHOENIX Combination Delivery System
- Other names
- BMACautologous bone marrow-derived stem cellsTMR + BMAC
Beyond the preview
Go deeper on bone marrow aspirate concentrate (Cardiogenesis).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on bone marrow aspirate concentrate (Cardiogenesis).