bone marrow concentrate + core decompression

This intervention is a combination therapy consisting of the surgical procedure core decompression and the implantation of autologous bone marrow concentrate (BMC). Core decompression is a standard surgical technique used to reduce intraosseous pressure and promote revascularization in early-stage avascular necrosis (osteonecrosis) of the femoral head. BMC is a biological product obtained by harvesting the patient's own bone marrow (typically from the iliac crest) and concentrating the mononuclear cell fraction, which includes mesenchymal stem cells (MSCs), hematopoietic stem cells, and various growth factors, via density gradient centrifugation. The goal of combining BMC with core decompression is to provide a concentrated source of osteogenic progenitor cells to enhance bone repair and regeneration within the necrotic lesion. In clinical trials conducted at Erasme University Hospital, this procedure served as the active control arm for evaluating the efficacy of PREOB®, an ex vivo expanded autologous osteoblastic cell therapy.

Other names

Core decompression/BMC implantationautologous bone marrow concentrate implantationCore decompression/BMC implantation-Erasme University Hospital-avascular necrosis of femur head