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**Bone-Viva!** is a proprietary multi-ingredient oral nutraceutical marketed by NViroMune for nutritional support of bone metabolism and skeletal health in people with low bone mineral density, including osteopenia and osteoporosis. The formulation combines vitamin D3, vitamin K2, boron, silicon, zinc, copper, manganese, curcumin, beta-caryophyllene, and strontium. Its intended biological rationale is to support calcium and mineral handling, bone mineralization, collagen matrix formation, osteoblast-associated bone formation, and inflammatory pathways involved in bone remodeling. It is a dietary supplement rather than an FDA-approved pharmaceutical antiresorptive or anabolic osteoporosis therapy. An 18-month comparative study in women with osteopenia or osteoporosis evaluated Bone-Viva alone and alongside denosumab or romosozumab; the published report described stabilization or improvement of bone mineral density in the Bone-Viva groups, but the product remains a nutraceutical and not an approved treatment for osteoporosis. ([prnewswire.com](https://www.prnewswire.com/news-releases/new-research-published-in-the-european-journal-of-medicine-shows-promising-results-for-women-with-osteoporosis-and-osteopenia-302684652.html))
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