bOPV + nOPV2

bOPV + nOPV2 is a combination of two live attenuated oral poliovirus vaccines used for immunization against poliomyelitis. - **bOPV (bivalent oral polio vaccine)** contains attenuated strains of poliovirus types 1 and 3 and is used in routine immunization to protect against these serotypes. - **nOPV2 (novel oral polio vaccine type 2)** is a genetically modified version of the monovalent type 2 OPV designed to provide immunity against poliovirus type 2 while reducing the risk of reversion to neurovirulence and subsequent outbreaks of circulating vaccine-derived poliovirus type 2 (cVDPV2). The modifications in nOPV2 increase its genetic stability by altering specific regions in the viral genome, making it less likely to revert or recombine into more virulent forms[1][4][5]. Both components act by inducing mucosal and systemic immunity through replication in the gut, stimulating both humoral and intestinal immune responses. This combination may be deployed during outbreak response or as part of tailored immunization strategies where all three serotypes are targeted using different formulations[3][5].

Other names

bivalent oral polio vaccine + novel oral polio vaccine type 2bivalent OPV + novel OPV2