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botulinum toxin A + tadalafil
- Development stage
- Unknown
- Lead developer
- Aswan University Hospital
- Modality
- Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Oral, Intracavernosal
01
Overview
This combination therapy is being investigated by Aswan University Hospital for the treatment of refractory erectile dysfunction in diabetic men. Botulinum toxin A (BoNT-A) is administered via intracavernosal injection to facilitate long-acting cavernosal smooth muscle relaxation by inhibiting the release of noradrenaline from adrenergic neurons. This is combined with daily oral tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor that enhances the nitric oxide-cGMP pathway to further promote penile blood flow and erection maintenance. The dual approach aims to address insufficient smooth muscle relaxation and veno-occlusive disorder in patients who do not respond to standard oral or intracorporeal vasoactive treatments.
- Other names
- Botulinum toxin A + Tadalafil 5mgBoNT-A + Tadalafil
02
Targets
SNAP25 (Synaptosome-associated protein 25)PDE5 (Phosphodiesterase 5A)
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