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Drug intelligence / Profile preview
brigatinib + binimetinib
- Development stage
- Discontinued
- Lead developer
- Takeda
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Brigatinib + binimetinib is an investigational **oral combination therapy consisting of brigatinib, an anaplastic lymphoma kinase (ALK) inhibitor, and binimetinib, a selective inhibitor of mitogen-activated protein kinase kinases 1 and 2 (MEK1/2)**. Brigatinib blocks ALK-mediated and mutant epidermal growth factor receptor (EGFR) signaling, inhibiting tumor cell proliferation and survival in ALK-positive cancers. Binimetinib targets MEK1/2 to interrupt the RAS/RAF/MEK/ERK signaling cascade and reduce tumor cell proliferation. The combination is under investigation for unresectable or metastatic non-small cell lung cancer (NSCLC), especially for ALK-positive or resistant cases, aiming to address resistance mechanisms to ALK inhibition.
- Other names
- brigatinib and binimetinib
02
Targets
ALK (Anaplastic lymphoma kinase receptor tyrosine kinase)EGFR (Epidermal growth factor receptor)MEK1 (Dual specificity mitogen-activated protein kinase kinase 1)MEK2 (Dual specificity mitogen-activated protein kinase kinase 2)
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