brimonidine + pilocarpine

Brimonidine + pilocarpine is a combination ophthalmic drug composed of two active ingredients, brimonidine and pilocarpine, both of which are used to lower intraocular pressure in conditions such as open-angle glaucoma and ocular hypertension. Brimonidine is an alpha-2 adrenergic receptor agonist that reduces aqueous humor production and increases uveoscleral outflow, thereby lowering intraocular pressure. Pilocarpine is a cholinergic (muscarinic) receptor agonist that induces miosis (pupil constriction) and increases trabecular meshwork outflow of aqueous humor. The combination leverages complementary mechanisms to enhance intraocular pressure reduction compared to monotherapy with either agent alone.