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broccoli sprout + broccoli seed extract
- Development stage
- Unknown
- Lead developer
- Nutramax Laboratories
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Broccoli sprout + broccoli seed extract, marketed under the brand name Avmacol®, is a botanical dietary supplement and natural product derived from broccoli sprout and seed extract powder. Its primary active ingredient is glucoraphanin, a glucosinolate that is hydrolyzed in the body to sulforaphane. Sulforaphane is a potent inducer of the Nuclear factor erythroid 2-related factor 2 (NRF2) pathway, which regulates the expression of cytoprotective phase II enzymes. By upregulating this pathway, the supplement enhances the detoxification and elimination of environmental toxins and tobacco-related carcinogens, such as benzene, acrolein, and crotonaldehyde. It is being developed and studied by the National Cancer Institute (NCI) Division of Cancer Prevention as a chemopreventive agent specifically for current heavy smokers to reduce the risk of tobacco-related carcinomas.
- Brand names
- AvmacolAvmacol ES
- Other names
- broccoli sprout/broccoli seed extract supplementbroccoli sprout and seed extract powder
02
Targets
KEAP1 (Kelch-like ECH-associated protein 1)GSH/LMWT (Glutathione and other low-molecular-weight thiols)HDAC (HDAC family)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)
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