Drug intelligence / Profile preview

bromhexine + ephedrine

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

Bromhexine + ephedrine is a fixed-dose combination therapy used to treat respiratory disorders characterized by excessive mucus production and bronchospasm. Bromhexine acts as a mucolytic agent, increasing the production of serous mucus and depolymerizing acid mucopolysaccharide fibers to reduce phlegm viscosity, thereby facilitating expectoration. Ephedrine is a sympathomimetic amine that acts as a bronchodilator by stimulating beta-2 adrenergic receptors in the airway smooth muscle and as a decongestant through alpha-adrenergic stimulation. This combination is typically indicated for conditions such as chronic bronchitis, bronchial asthma, and chronic obstructive pulmonary disease (COPD) where both airway obstruction and impaired mucus clearance are present.

Brand names
Bromhexine and Ephedrine Elixir
Other names
bromhexine hydrochloride + ephedrine hydrochloride
02

Targets

ADRA1A (α1A)ADRB2 (β2)ADRB3 (β3)ADRB1 (β1)

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