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BT5528 (BicycleTx)
- Development stage
- Preclinical
- Lead developer
- Bicycle Therapeutics
01
Overview
BT5528 (BicycleTx): sourced facts only. name: "BT5528 is a Bicycle® Drug Conjugate (BDC®), comprising a highly selective EphA2-targeting bicyclic peptide conjugated to the cytotoxin MMAE via a stable valine-citrulline cleavable linker." [DOI:10.1158/1538-7445.am2026-1325]; target: "BT5528 is a Bicycle® Drug Conjugate (BDC®), comprising a highly selective EphA2-targeting bicyclic peptide conjugated to the cytotoxin MMAE via a stable valine-citrulline cleavable linker." [DOI:10.1158/1538-7445.am2026-1325]; developer: "1BicycleTx Ltd, Cambridge, United Kingdom;" [DOI:10.1158/1538-7445.am2026-1325]; modality: "BT5528 is a Bicycle® Drug Conjugate (BDC®), comprising a highly selective EphA2-targeting bicyclic peptide conjugated to the cytotoxin MMAE via a stable valine-citrulline cleavable linker." [DOI:10.1158/1538-7445.am2026-1325]; stage: "BT5528 has shown potent preclinical anti-tumor activity in EphA2-expressing CDX models of HNSCC at clinically relevant doses." [DOI:10.1158/1538-7445.am2026-1325]
02
Targets
EPHA2 (Ephrin type-A receptor 2)
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