Drug intelligence / Profile preview

budesonide + formoterol + acebrophylline + montelukast + levocetirizine

Development stage
Unknown
Lead developer
AstraZeneca
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Inhalation, Oral
01

Overview

This is a fixed-dose combination medication containing five active pharmaceutical ingredients: - **Budesonide** (an inhaled corticosteroid that reduces airway inflammation) - **Formoterol** (a long-acting beta-2 adrenergic receptor agonist, or LABA, that relaxes bronchial smooth muscle) - **Acebrophylline** (a bronchodilator and mucoregulator with anti-inflammatory properties, related to xanthines) - **Montelukast** (a leukotriene receptor antagonist that blocks leukotriene-mediated airway inflammation and bronchoconstriction) - **Levocetirizine** (a second-generation antihistamine that blocks histamine H1 receptors to reduce allergic symptoms) The combination is designed for the management of respiratory disorders such as asthma, chronic obstructive pulmonary disease (COPD), allergic rhinitis, and other conditions involving airway inflammation and hypersensitivity. Each component targets different pathways involved in respiratory disease pathophysiology—providing anti-inflammatory effects, bronchodilation, mucoregulation, leukotriene antagonism, and antihistaminic action[1][5][8][10].

02

Targets

GR (Glucocorticoid receptor)ADRB2 (β2)HRH1 (Histamine H1 Receptor)ADOR (Adenosine receptors)CYSLTR1 (Cysteinyl-leukotriene type 1 receptor)PDE (Phosphodiesterase family)

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