Drug intelligence / Profile preview

budesonide + glycopyrronium bromide + formoterol fumarate

Development stage
Unknown
Lead developer
Shandong Jingwei Pharmaceutical
Modality
Small Molecules
Administration
Inhalation
01

Overview

JW202313 is a fixed-dose triple combination inhalation powder developed by Shandong Jingwei Pharmaceutical for the treatment of chronic obstructive pulmonary disease (COPD). It consists of three active ingredients: budesonide, an inhaled corticosteroid (ICS) that reduces airway inflammation; glycopyrronium bromide, a long-acting muscarinic antagonist (LAMA) that blocks muscarinic receptors to prevent bronchoconstriction; and formoterol fumarate, a long-acting beta2-adrenergic agonist (LABA) that stimulates beta2-adrenoceptors to induce bronchodilation. This combination therapy is designed to provide comprehensive management of COPD symptoms and reduce the frequency of exacerbations. It is currently being evaluated in Phase II clinical trials in China as a potential generic alternative or new formulation equivalent to existing triple therapies like Breztri Aerosphere, but delivered via a dry powder inhaler (DPI) rather than a metered-dose inhaler.

Other names
budesonide/glycopyrronium bromide/formoterol fumarate inhalation powder布地奈德格隆溴铵福莫特罗吸入粉雾剂
02

Targets

CHRM3 (M3)GR (Glucocorticoid receptor)ADRB2 (β2)

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