Drug intelligence / Profile preview

budesonide + gubenkechuan

Development stage
Preclinical
Lead developer
Hefei Lifeon Pharmaceutical
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Inhalation, Oral
01

Overview

This is a combination product containing budesonide, a synthetic glucocorticoid corticosteroid with potent anti-inflammatory properties, and Gubenkechuan (also known as Gubenkechuan Keli), a traditional Chinese medicine formulation. Budesonide acts primarily by binding to the glucocorticoid receptor and modulating gene expression to suppress inflammation in the airways or gastrointestinal tract[3][5]. Gubenkechuan Keli is used in China for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and may contain multiple herbal ingredients aimed at supporting lung function and reducing symptoms like cough, wheezing, and shortness of breath[6][10]. The combination aims to leverage both Western pharmacological anti-inflammatory effects (from budesonide) and traditional Chinese medicine approaches (from Gubenkechuan) for synergistic management of chronic respiratory conditions.

02

Targets

GR (Glucocorticoid receptor)

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