budesonide + lidocaine

This combination therapy consists of **budesonide**, a synthetic glucocorticoid corticosteroid, and **lidocaine**, a local anesthetic of the amide type. It is being investigated by **Qianfoshan Hospital** for the prevention and treatment of postoperative sore throat (POST) in patients undergoing thyroidectomy with nerve monitoring. Budesonide acts as an anti-inflammatory agent by binding to glucocorticoid receptors, thereby reducing mucosal edema and inflammation caused by tracheal intubation and surgical positioning. Lidocaine provides local anesthesia by blocking voltage-gated sodium channels, which inhibits the conduction of pain impulses from the laryngeal and tracheal mucosa. The combination is administered via glottic nebulization to provide targeted, non-invasive relief at the site of potential injury.

Other names

budesonide and lidocaine combinationglottic nebulization of budesonide and lidocaine