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budesonide + salmeterol
- Development stage
- Unknown
- Lead developer
- SMB Laboratories
- Modality
- Small Molecules
- Administration
- Inhalation
01
Overview
**Budesonide + salmeterol** is a fixed-dose inhaled combination of budesonide, an inhaled corticosteroid, and salmeterol, a long-acting beta-2 adrenergic agonist. Budesonide activates the glucocorticoid receptor to suppress inflammatory signaling, airway edema, and inflammatory-cell activity, while salmeterol provides prolonged beta-2 adrenergic receptor-mediated bronchodilation. The combination is used as maintenance treatment for asthma; marketed European dry-powder capsule products include Busalair, Zephirus, Desoterol, Duastmin, and ReviX Axahaler. It is not intended for rapid relief of acute bronchospasm.
- Brand names
- BusalairDesoterolDuastminReviX AxahalerZephirus
- Other names
- budesonide/salmeterolbudesonide/salmeterol xinafoateLabazenitsalmeterol + budesonidesalmeterol/budesonide
02
Targets
GR (Glucocorticoid receptor)ADRB2 (β2)
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