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buparlisib + carboplatin
- Development stage
- Unknown
- Lead developer
- Adlai Nortye
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Buparlisib (BKM120) plus carboplatin is an investigational combination therapy studied primarily in advanced solid tumors. Buparlisib is an orally available pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor that targets all class IA PI3K paralogues (p110α, β, and δ), disrupting the PI3K/AKT signaling pathway involved in cancer cell growth and survival. Carboplatin is a platinum-based chemotherapeutic agent that induces DNA crosslinking and apoptosis in rapidly dividing cells. The rationale for combining these agents is based on preclinical evidence that PI3K inhibition can sensitize tumor cells to platinum-based chemotherapy. This combination has been evaluated in phase I clinical trials for patients with advanced solid tumors to determine safety, tolerability, and recommended dosing[1][2]. Preliminary results indicate manageable toxicity and some antitumor activity.
- Brand names
- none
- Other names
- BKM120 + carboplatinbuparlisib + carboplatin
02
Targets
PIK3CG (Phosphatidylinositol 4,5-bisphosphate 3-kinase gamma)PIK3CD (Phosphatidylinositol 3-kinase delta)PIK3CB (Phosphatidylinositol 3-kinase beta subunit)TUBB (Tubulin (alpha and beta subunits))DNAPIK3CA (Phosphoinositide 3-kinase alpha)
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