bupivacaine + celecoxib

This is a combination drug consisting of bupivacaine, an amide-type local anesthetic, and celecoxib, a selective nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase-2 (COX-2). Bupivacaine acts by reversibly blocking voltage-gated sodium channels in neuronal membranes, thereby inhibiting nerve impulse transmission and providing local or regional anesthesia. Celecoxib selectively inhibits COX-2 to reduce the synthesis of prostaglandins involved in inflammation and pain signaling. The combination is designed for enhanced pain control—bupivacaine provides immediate local anesthesia while celecoxib offers sustained anti-inflammatory and analgesic effects. This type of formulation may be used for perioperative or postoperative pain management, potentially as a long-acting depot or slow-release system administered locally at the surgical site[2][7][5].

Other names

盐酸布比卡因 + 塞来昔布