bupivacaine + dexamethasone (Lifespan Biotech)

This intervention is a combination of the amide-type local anesthetic **bupivacaine** and the synthetic glucocorticoid **dexamethasone**, specifically evaluated as a perineural adjuvant in regional anesthesia. In clinical practice, particularly for shoulder surgeries, dexamethasone is added to local anesthetics like bupivacaine for interscalene nerve blocks to significantly prolong the duration of sensory and motor blockade and improve postoperative analgesia. The clinical trial context provided by **Lifespan** (NCT02343315) specifically investigates the systemic metabolic impact of this combination, hypothesizing that the 8 mg dose of dexamethasone used as an adjuvant does not cause a significant increase in plasma glucose levels in non-diabetic patients undergoing shoulder surgery.

Brand names

DecadronMarcaineSensorcaine

Other names

Dexamethasone as adjuvant to interscalene blockPerineural dexamethasoneDexamethasone + bupivacaine