Drug intelligence / Profile preview

bupivacaine + fentanyl

Development stage
Phase 4
Lead developer
AstraZeneca
Modality
Small Molecules
Administration
Epidural, Intrathecal
01

Overview

Bupivacaine + fentanyl is a combination medication used for pain management, particularly in epidural and intrathecal (spinal) analgesia. This combination leverages the synergistic interaction between these two medications to provide effective pain relief with potentially fewer side effects than higher doses of either medication alone. Bupivacaine is an amide local anesthetic that blocks nerve impulse generation and conduction, while fentanyl is an opioid analgesic that acts on the central nervous system. The combination is commonly used for labor pain relief, post-surgical pain management, and in the management of chronic pain through intrathecal drug delivery systems.

Brand names
MarcaineSensorcaineSublimaze
Other names
bupivacaine + fentanylfentanyl + bupivacaine
02

Targets

MOR (Mu opioid receptor)NaV (Voltage-gated sodium channels)PTGER1 (Prostaglandin E Receptor 1)

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