bupivacaine + fentanyl + morphine

Standardized Spinal Mixture is a combination analgesic solution used for intrathecal administration, primarily in the context of obstetric anesthesia for cesarean sections. The mixture typically comprises hyperbaric bupivacaine, a local anesthetic that blocks voltage-gated sodium channels to provide surgical anesthesia; fentanyl, a rapid-onset mu-opioid receptor agonist for immediate intraoperative analgesia; and preservative-free morphine, a long-acting mu-opioid receptor agonist for extended postoperative pain relief. This specific formulation is utilized as a baseline regimen in clinical trials, such as those sponsored by the Icahn School of Medicine at Mount Sinai, to evaluate the efficacy of additional adjuvants like dexmedetomidine or epinephrine in enhancing the duration and quality of the spinal block.

Other names

Standardized Spinal Mixture