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bupivacaine + fentanyl + morphine (AstraZeneca)
- Development stage
- Phase 4
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Intrathecal
01
Overview
This is a combination medication used primarily for spinal anesthesia and analgesia, particularly in obstetric procedures such as cesarean sections and labor pain management. The combination leverages the complementary properties of each component: bupivacaine (a local anesthetic) provides regional anesthesia, while fentanyl (a lipophilic opioid) offers rapid onset of analgesia, and morphine (a hydrophilic opioid) provides prolonged postoperative pain relief. This combination has been shown to improve perioperative analgesia compared to single agents, with studies demonstrating reduced breakthrough pain and decreased postoperative medication requirements.
- Other names
- intrathecal opioids adjuvantmorphine + fentanyl + bupivacaine (St. Justine formulation)
02
Targets
MOR (Mu opioid receptor)NaV (Voltage-gated sodium channels)
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